Effects of adrenergic neurone blocking agents on guinea pig ileum.

Sharma and Rajapurkar (~) while studying the actions of adrenergic neurone blocking drugs on intestinal peristalsis observed that bretyliurn and xylocholine in bigger doses produced a stimulant response on the longitudinal moveme-nts of guinea pig ileum where as guanethidine had no stimulant action (unreported observations). Those observations are in consonance witb tbe observations of Boura and Green (2), wbo however, did not investigate the stimulant response further. We Studied the response in detail in this laboratory and have some interesting observations which are reported in this paper .